abstract：BACKGROUND:Hyaline articular cartilage, which protects the bones of diarthrodial joints from forces associated with load bearing, frictions, and impacts has very limited capacities for self-repair. Over the years, the trend of treatments has shifted to regenerations and researchers have been on the quest for a lasting ...

journal_title：Experimental gerontology

authors： Ude CC,Shamsul BS,Ng MH,Chen HC,Ohnmar H,Amaramalar SN,Rizal AR,Johan A,Norhamdan MY,Azizi M,Aminuddin BS,Ruszymah BHI

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Longitudinal studies on sleep duration and grip strength decline are limited. This study aimed to evaluate the associations of baseline sleep duration with follow-up grip strength and grip strength changeover time among a large sample of middle-aged and older Chinese. METHODS:Data from China Health and Reti...

journal_title：Experimental gerontology

authors： Wang TY,Wu Y,Wang T,Li Y,Zhang D

更新日期：2018-03-01 00:00:00

abstract：:Age-related declines in human skeletal muscle performance may be caused, in part, by decreased responsivity of muscle fibers to calcium (Ca2+). This study examined the contractile properties of single vastus lateralis muscle fibers with various myosin heavy chain (MHC) isoforms (I, I/IIA, IIA and IIAX) across a range ...

journal_title：Experimental gerontology

authors： Straight CR,Ades PA,Toth MJ,Miller MS

更新日期：2018-02-01 00:00:00

abstract：:Homeostenosis (i.e. decline in stress resistance and resilience with age) is a fundamental notion of the biogerontology and physiology of aging. Stressful situations typically challenge metabolic homeostasis and the capacity to recover from a stress-induced metabolic disorder might be particularly compromised in senes...

journal_title：Experimental gerontology

authors： Colinet H,Renault D

更新日期：2018-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has been identified as a potential treatment for effectively improving cognitive function in several neuropathological conditions. However, the underlying mechanism and the relevant downstream protective pathways that are activated in neurons by VEGF remain elusive, especially...

journal_title：Experimental gerontology

authors： Wang L,Wang F,Liu S,Yang X,Yang J,Ming D

更新日期：2018-02-01 00:00:00

abstract：:Pioglitazone (Piog) activates peroxisome proliferator activated receptor-γ (PPARγ) and is widely used in clinic for the treatment of diabetes mellitus. PPARγ in various tissues has the essential regulatory role of multiple metabolic function, suggest that PPARγ signaling may contribute to aging processes. However, lit...

journal_title：Experimental gerontology

authors： Shen D,Li H,Zhou R,Liu MJ,Yu H,Wu DF

更新日期：2018-02-01 00:00:00

abstract：:Cardiovascular disease (CVD) is an important public health problem affecting especially the elderly. Over the past 20years, an increasing number of studies have examined its underlying pathophysiological mechanisms and new therapies are continually being discovered. However, despite considerable progress in CVD manage...

journal_title：Experimental gerontology

authors： Recchioni R,Marcheselli F,Antonicelli R,Mensà E,Lazzarini R,Procopio AD,Olivieri F

更新日期：2017-12-15 00:00:00

abstract：:Rodent animal models take at least 18months to develop aging phenotypes for researchers to investigate the mechanism of age-related metabolic complications. Senescence-accelerated mouse prone 8 (SAMP8) shortens the process of aging and may facilitate an alternative model for studying age-related insulin resistance. Th...

journal_title：Experimental gerontology

authors： Liu HW,Chan YC,Wei CC,Chen YA,Wang MF,Chang SJ

更新日期：2017-12-01 00:00:00

abstract：:This study aimed to analyze the effects of resistance training associated with testosterone administration in the neuromuscular junction (NMJ) postsynaptic region of different skeletal muscle types of aged rats. Wistar rats were divided into: SEI - 20-months-old control, SEF - 24-months-old control, T - 20-months-old ...

journal_title：Experimental gerontology

authors： Krause Neto W,de Assis Silva W,Ciena AP,Anaruma CA,Gama EF

更新日期：2017-11-01 00:00:00

abstract：:Aging is associated with changes in several metabolic pathways affecting liver function including the adaptive unfolded protein response (UPR). On the other hand, exercise training has been shown to exert beneficial effects on metabolism in the liver and exercise training has been reported to affect hepatic UPR. PGC-1...

journal_title：Experimental gerontology

authors： Kristensen CM,Brandt CT,Ringholm S,Pilegaard H

更新日期：2017-11-01 00:00:00

abstract：:We tested the hypothesis that hesperidin would reverse age-related aortic stiffness, perivascular adipose (PVAT) mediated-arterial stiffening and PVAT advanced glycation end-products (AGE) accumulation. Aortic pulse wave velocity (aPWV) and intrinsic mechanical stiffness, two measures of arterial stiffness, were asses...

journal_title：Experimental gerontology

authors： Ouyang A,Garner TB,Fleenor BS

更新日期：2017-10-15 00:00:00

abstract：:Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little atte...

journal_title：Experimental gerontology

authors： Dovjak P,Heinze G,Rainer A,Sipos W,Pietschmann P

更新日期：2017-10-01 00:00:00

abstract：:Aging is associated with impaired mitochondrial function, whereas exercise training enhances mitochondrial content and function in part through activation of PGC-1α. Mitochondria form dynamic networks regulated by fission and fusion with profound effects on mitochondrial functions, yet the effects of aging and exercis...

journal_title：Experimental gerontology

authors： Halling JF,Ringholm S,Olesen J,Prats C,Pilegaard H

更新日期：2017-10-01 00:00:00

abstract：:Natural killer (NK) cells play an important role in controlling several viral diseases. Our previous studies demonstrated an age-dependent susceptibility to mousepox due to defective NK cell responses and trafficking. However, the mechanisms that underlie the age-related impairment in NK cell migration have yet to be ...

journal_title：Experimental gerontology

authors： Duan X,Lu J,Wang H,Liu X,Wang J,Zhou K,Jiang W,Wang Y,Fang M

更新日期：2017-10-01 00:00:00

abstract：:Recent deep sequencing studies on T-cell receptor (TCR) repertoire have provided robust data to characterize diversity of T-cell immune responsiveness to a wide variety of peptide antigens, including viral and tumor antigens. The human TCR repertoire declines with age, but this decline has not been fully investigated ...

journal_title：Experimental gerontology

authors： Yoshida K,Cologne JB,Cordova K,Misumi M,Yamaoka M,Kyoizumi S,Hayashi T,Robins H,Kusunoki Y

更新日期：2017-10-01 00:00:00

abstract：:Estrogens are potent and efficacious neuroprotectants both in vitro and in vivo in a variety of models of neurotoxicity. We determined the structural requirements for neuroprotection in an in vitro assay using a panel of >70 novel estratrienes, synthesized to reduce or eliminate estrogen receptor (ER) binding. We obse...

journal_title：Experimental gerontology

authors： Engler-Chiurazzi EB,Covey DF,Simpkins JW

更新日期：2017-08-01 00:00:00

abstract：:Methionine restriction (MR) extends lifespan across different species. The main responses of rodent models to MR are well-documented in adipose tissue (AT) and liver, which have reduced mass and improved insulin sensitivity, respectively. Recently, molecular mechanisms that improve healthspan have been identified in b...

journal_title：Experimental gerontology

authors： Ables GP,Johnson JE

更新日期：2017-08-01 00:00:00

abstract：:Female mammals undergo natural fluctuations in sex steroid hormone levels throughout life. These fluctuations span from early development, to cyclic changes associated with the menstrual or estrous cycle and pregnancy, to marked hormone flux during perimenopause, and a final decline at reproductive senescence. While t...

journal_title：Experimental gerontology

authors： Koebele SV,Bimonte-Nelson HA

更新日期：2017-08-01 00:00:00

abstract：:SAMP8 mice exhibit multiple metabolic characteristics associated with age, and it is a suitable candidate for researching aging associated metabolic dysfunction. OBJECTIVES:We aimed to 1) explore how key metabolic markers will be altered in both liver and adipose tissue with aging in SAMP8 mice; and 2) how the combin...

journal_title：Experimental gerontology

authors： Rui Y,Cheng J,Qin L,Shan C,Chang J,Wang G,Wan Z

更新日期：2017-07-01 00:00:00

abstract：:In this study we report the identification of FAH domain containing protein 1 (FAHD1), a recently described member of the fumarylacetoacetate hydrolase (FAH) superfamily of metabolic enzymes, as a novel player in the regulation of cellular senescence. FAHD1 was found in a proteomic screen searching for mitochondrial p...

journal_title：Experimental gerontology

authors： Petit M,Koziel R,Etemad S,Pircher H,Jansen-Dürr P

更新日期：2017-06-01 00:00:00

abstract：:Hospitalization may induce a decrease of muscle strength and muscle mass in older patients due to physical inactivity, malnutrition and diseases, negatively affecting health outcome. We aimed to examine the literature on change in muscle strength and muscle mass in older patients during hospitalization. A literature s...

journal_title：Experimental gerontology

authors： Van Ancum JM,Scheerman K,Jonkman NH,Smeenk HE,Kruizinga RC,Meskers CGM,Maier AB

更新日期：2017-06-01 00:00:00

abstract：:In mammals, the relationship between reproductive function and health has been particularly difficult to define. Previously, in old, postreproductive-aged mice, replacement of senescent ovaries with new ovaries from young, actively cycling mice increased life span. We hypothesized that the same factors that increased ...

journal_title：Experimental gerontology

authors： Parkinson KC,Peterson RL,Mason JB

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs). METHODS:Alzheimer's Disease Neuroimaging Initiative cohort (ADNI...

journal_title：Experimental gerontology

authors： Fardo DW,Katsumata Y,Kauwe JSK,Deming Y,Harari O,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative.,Nelson PT

更新日期：2017-04-01 00:00:00

abstract：:Perimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that result in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant suppleme...

journal_title：Experimental gerontology

authors： Pereira AAF,Tirapeli KG,Chaves-Neto AH,da Silva Brasilino M,da Rocha CQ,Belló-Klein A,Llesuy SF,Dornelles RCM,Nakamune ACMS

更新日期：2017-04-01 00:00:00

abstract：:Alpha-synuclein (α-Syn) accumulation is significantly correlated with motor deficits and mitochondrial dysfunction in Parkinson's disease (PD), but the molecular mechanism underlying its pathogenesis is unclear. In this study, we investigated the effects of treadmill exercise on motor deficits and mitochondrial dysfun...

journal_title：Experimental gerontology

authors： Koo JH,Cho JY,Lee UB

更新日期：2017-03-01 00:00:00

abstract：:Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR diet alters DNA methyl...

journal_title：Experimental gerontology

authors： Mattocks DA,Mentch SJ,Shneyder J,Ables GP,Sun D,Richie JP Jr,Locasale JW,Nichenametla SN

更新日期：2017-02-01 00:00:00

abstract：:Given the increased concerns about the degenerative decline in the physical performance of the elderly, there is a need for developing effective strategies to suppress the age-related loss of skeletal muscle mass and functional capacity through a lifestyle intervention. This randomized controlled trial examined whethe...

journal_title：Experimental gerontology

authors： Lim NJ,Shin JH,Kim HJ,Lim Y,Kim JY,Lee WJ,Han SJ,Kwon O

更新日期：2017-01-01 00:00:00

abstract：:Mitochondrial dysfunction is involved in the loss of muscle featuring both aging and cancer cachexia (CC). Whether mitochondrial quality control (MQC) is altered in skeletal myocytes of old patients with CC is unclear. The present investigation therefore sought to preliminarily characterize MQC pathways in muscle of o...

journal_title：Experimental gerontology

authors： Marzetti E,Lorenzi M,Landi F,Picca A,Rosa F,Tanganelli F,Galli M,Doglietto GB,Pacelli F,Cesari M,Bernabei R,Calvani R,Bossola M

更新日期：2017-01-01 00:00:00

abstract：:Diet is the most variable aspect of life history, as most individuals have a large diversity of food choices, varying in the type and amount that they ingest. In the short-term, diet can affect metabolism and energy levels. However, in the long run, the net deficiency or excess of calories from diet can influence the ...

journal_title：Experimental gerontology

authors： Yen CA,Curran SP

更新日期：2016-12-15 00:00:00

abstract：OBJECTIVE:To compare body composition as assessed by conventional and vector bioelectrical impedance analysis according to the nutritional cataloging using body mass index (BMI) in a group of institutionalized elderly. METHODS:Cross-sectional study in 38 institutionalized elderly. Body composition was estimated by bio...

journal_title：Experimental gerontology

authors： Redondo-Del-Río MP,Camina-Martín MA,Moya-Gago L,de-la-Cruz-Marcos S,Malafarina V,de-Mateo-Silleras B

更新日期：2016-12-01 00:00:00

abstract：:Rats of Albino Oxford (AO) strain in our animal facility exhibit a longer average healthy life span than rats of Dark Agouit (DA) strain. Since chronic activation of macrophages contributes to chronic low level inflammation common in older age, elucidation of the changes in middle-aged rats could be useful in preventi...

journal_title：Experimental gerontology

authors： Stanojević S,Ćuruvija I,Blagojević V,Petrović R,Vujić V,Dimitrijević M

更新日期：2016-12-01 00:00:00

abstract：:The slow and continuous loss of muscle mass that progresses with aging is defined as "sarcopenia". Sarcopenia represents an important public health problem, being closely linked to a condition of frailty and, therefore, of disability. According to the European Working Group on Sarcopenia in Older People, the diagnosis...

journal_title：Experimental gerontology

authors： Curcio F,Ferro G,Basile C,Liguori I,Parrella P,Pirozzi F,Della-Morte D,Gargiulo G,Testa G,Tocchetti CG,Bonaduce D,Abete P

更新日期：2016-12-01 00:00:00

abstract：:The dependent elderly are widely considered to be at higher risk of nutritional problems. Suboptimal micronutrient intake might put the elderly, especially those living in nursing homes, at high risk of morbidity. So far, no public authority, except for the Israel Ministry of Health, has issued particular recommendati...

journal_title：Experimental gerontology

authors： Tal S,Stern F,Polyak Z,Ichelzon I,Dror Y

更新日期：2016-11-01 00:00:00

abstract：:Advanced paternal age is associated with increased complications in pregnancy and genetic diseases in offspring. Oxidative stress is a major contributor to the damage accumulated in sperm during aging. Complex networks of antioxidants regulate reactive oxygen species (ROS) in the testis. While mounting evident shows t...

journal_title：Experimental gerontology

authors： Selvaratnam J,Robaire B

更新日期：2016-11-01 00:00:00

abstract：:The CG9940 gene, which encodes the NAD(+) synthase protein in Drosophila, is conserved in human, zebra fish, and mosquito. NAD(+) synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic a...

journal_title：Experimental gerontology

authors： Wen DT,Zheng L,Ni L,Wang H,Feng Y,Zhang M

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:The present study investigated whether the performance on executive function tasks of patients with type 2 diabetes mellitus (T2DM) is as impaired as that of Alzheimer's disease (AD) patients and to compare their performance with that of a group of cognitively healthy older adults. We also investigated wheth...

journal_title：Experimental gerontology

authors： Redondo MT,Beltrán-Brotóns JL,Reales JM,Ballesteros S

更新日期：2016-10-01 00:00:00

abstract：:Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to increase longevity in mice (14mgofrapamycin/kg of diet). Middle aged mice (16m...

journal_title：Experimental gerontology

authors： Martínez-Cisuelo V,Gómez J,García-Junceda I,Naudí A,Cabré R,Mota-Martorell N,López-Torres M,González-Sánchez M,Pamplona R,Barja G

更新日期：2016-10-01 00:00:00

abstract：:A decline in instrumental activities of daily living has been described as the earliest functional deficit in patients with neurodegenerative disease. It embraces specific competencies such as: "recalling the date and telephone calls, orienting to new places, remembering the location of objects at home, understanding ...

journal_title：Experimental gerontology

authors： Amanzio M,D'Agata F,Palermo S,Rubino E,Zucca M,Galati A,Pinessi L,Castellano G,Rainero I

更新日期：2016-10-01 00:00:00

abstract：:We develop a theoretical model from an energetic viewpoint for unraveling the entangled effects of metabolic and biosynthetic rates on oxidative cellular damage accumulation during animal's growth, and test the model by experiments in hornworms. The theoretical consideration suggests that most of the cellular damages ...

journal_title：Experimental gerontology

authors： Amunugama K,Jiao L,Olbricht GR,Walker C,Huang YW,Nam PK,Hou C

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whet...

journal_title：Experimental gerontology

authors： Perna L,Mons U,Schöttker B,Brenner H

更新日期：2016-08-01 00:00:00